ea0090oc6.4 | Oral Communications 6: Endocrine-related Cancer | ECE2023
Philipp Schauer Marc
, Landwehr Laura-Sophie
, Justus Weber
, Altieri Barbara
, Rodrigo Redundo-Frutos
, Tanja Maier
, Daniel Oppelt
, Kroiss Matthias
, Sbiera Silviu
, Michael Hudecek
, Fassnacht Martin
Background: Adrenocortical carcinoma (ACC) is a very rare and aggressive, endocrine malignancy with still limited treatment options. Approximately 60% of patients with ACC show endogenous glucocorticoid excess which could be one potential cause, why first clinical trials with immunotherapies, like immune checkpoint inhibitors, showed only modest results. Due to the lack of an ACC-specific antigen structure, other immunotherapeutic approaches, like specialized cancer treatments...